| 2023 | Lessons in Chemistry | British Book Awards source ↗ (opens in a new tab) | Shortlist · Debut Book of the Year | |
| 2023 | Lessons in Chemistry | Dublin Literary Award source ↗ (opens in a new tab) | Longlist · Fiction | |
| 2022 | Lessons in Chemistry | Barnes & Noble Book of the Year source ↗ (opens in a new tab) | Winner · Book of the Year | |
| 2022 | Lessons in Chemistry | Goodreads Choice Awards source ↗ (opens in a new tab) | Winner · Debut Novel | |
| 2022 | Lessons in Chemistry | Waterstones Book of the Year source ↗ (opens in a new tab) | Shortlist · Book of the Year | |
| 2022 | Lessons in Chemistry | Goodreads Choice Awards source ↗ (opens in a new tab) | Nominee · Historical Fiction | |
| 2022 | Lessons in Chemistry | Barnes & Noble Best Books of the Year source ↗ (opens in a new tab) | Selection · Best Books | |
| 2022 | Lessons in Chemistry: A Novel | NPR Books We Love source ↗ (opens in a new tab) | Selection · Books We Love | |
| 2022 | Lessons in Chemistry | The Irish Times Best Books of the Year source ↗ (opens in a new tab) | Selection · Books of the Year | |
| 2022 | Lessons in Chemistry | BookPage Best Books of the Year source ↗ (opens in a new tab) | Selection · Fiction | |
| 2022 | Lessons in Chemistry | Kirkus Best Books of the Year source ↗ (opens in a new tab) | Selection · Fiction | |
| 2022 | Lessons in Chemistry | The Guardian Best Books of the Year source ↗ (opens in a new tab) | Selection · Fiction | |
| 2022 | Lessons in Chemistry | New York Times 100 Notable Books source ↗ (opens in a new tab) | Selection · Fiction & Poetry | |