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- 1No One Is Talking About This: A NovelPatricia Lockwood · 2021 · 2 honors
- 2A Calling for Charlie Barnes: A NovelJoshua Ferris · 2021 · 1 honor
- 3A Lot Like AdiósAlexis Daria · 2021 · 1 honor
- 4A Passage North: A NovelAnuk Arudpragasam · 2021 · 1 honor
- 5A Thousand ShipsNatalie Haynes · 2021 · 1 honor
- 6Abundance: A NovelJakob Guanzon · 2021 · 1 honor
- 7Accidentally EngagedFarah Heron · 2021 · 1 honor
- 8Act Your Age, Eve Brown: A NovelTalia Hibbert · 2021 · 1 honor
- 9All the Feels: A NovelOlivia Dade · 2021 · 1 honor
- 10American Delirium: A NovelBetina González, translated by Heather Cleary · 2021 · 1 honor
- 11Beautiful World, Where Are You: A NovelSally Rooney · 2021 · 1 honor
- 12China Room: A NovelSunjeev Sahota · 2021 · 1 honor
- 13Crossroads: A NovelJonathan Franzen · 2021 · 1 honor
- 14Darryl: A NovelJackie Ess · 2021 · 1 honor
- 15Dear Miss Metropolitan: A NovelCarolyn Ferrell · 2021 · 1 honor
- 16Detransition Baby: A NovelTorrey Peters · 2021 · 1 honor
- 17Edge Case: A NovelYZ Chin · 2021 · 1 honor
- 18Fight Night: A NovelMiriam Toews · 2021 · 1 honor
- 19First Comes Like: A NovelAlisha Rai · 2021 · 1 honor
- 20Ghosts: A NovelDolly Alderton · 2021 · 1 honor
- 21Gold Diggers: A NovelSanjena Sathian · 2021 · 1 honor
- 22Great Circle: A NovelMaggie Shipstead · 2021 · 1 honor
- 23Happy Hour: A NovelMarlowe Granados · 2021 · 1 honor
- 24Hard Like WaterYan Lianke, translated by Carlos Rojas · 2021 · 1 honor
- 25Honey GirlMorgan Rogers · 2021 · 1 honor
- 26How Beautiful We WereImbolo Mbue · 2021 · 1 honor
- 27I Love You but I've Chosen Darkness: A NovelClaire Vaye Watkins · 2021 · 1 honor
- 28In the Country of Others: A NovelLeila Slimani · 2021 · 1 honor
- 29IntimaciesKatie Kitamura · 2021 · 1 honor
- 30Island Queen: A NovelVanessa Riley · 2021 · 1 honor
- 31Light Perpetual: A NovelFrancis Spufford · 2021 · 1 honor
- 32Martita, I Remember You / Martita, Te Recuerdo: A Story in English and SpanishSandra Cisneros · 2021 · 1 honor
- 33Mary Jane: A NovelJessica Anya Blau · 2021 · 1 honor
- 34Matrix: A NovelLauren Groff · 2021 · 1 honor
- 35Monkey Boy: A NovelFrancisco Goldman · 2021 · 1 honor
- 36Monster in the Middle: A NovelTiphanie Yanique · 2021 · 1 honor
- 37My Brilliant Life: A NovelAe-ran Kim, translated by Chi-Young Kim · 2021 · 1 honor
- 38Night Came With Many Stars: A NovelSimon Van Booy · 2021 · 1 honor
- 39Nives: A NovelSacha Naspini · 2021 · 1 honor
- 40Oh William!: A NovelElizabeth Strout · 2021 · 1 honor
- 41One Last Stop: A NovelCasey McQuiston · 2021 · 1 honor
- 42Outlawed: A NovelAnna North · 2021 · 1 honor
- 43People We Meet on VacationEmily Henry · 2021 · 1 honor
- 44Radha & Jai’s Recipe for RomanceNisha Sharma · 2021 · 1 honor
- 45Ramadan Ramsey: A NovelLouis Edwards · 2021 · 1 honor
- 46Red Island House: A NovelAndrea Lee · 2021 · 1 honor
- 47Seven Days in June: A NovelTia Williams · 2021 · 1 honor
- 48Silent Winds, Dry Seas: A NovelVinod Busjeet · 2021 · 1 honor
- 49Small Things Like TheseClaire Keegan · 2021 · 1 honor
- 50SummerwaterSarah Moss · 2021 · 1 honor
- 51The Chosen and the BeautifulNghi Vo · 2021 · 1 honor
- 52The City of Good Death: A NovelPriyanka Champaneri · 2021 · 1 honor
- 53The Dating PlaybookFarrah Rochon · 2021 · 1 honor
- 54The Ex Talk: A NovelRachel Lynn Solomon · 2021 · 1 honor
- 55The Final Revival of Opal and NevDawnie Walton · 2021 · 1 honor
- 56The Five Wounds: A NovelKristin Valdez Quade · 2021 · 1 honor
- 57The Guncle: A NovelSteven Rowley · 2021 · 1 honor
- 58The Heart Principle: A NovelHelen Hoang · 2021 · 1 honor
- 59The Liar's Dictionary: A NovelEley Williams · 2021 · 1 honor
- 60The Life of the Mind: A NovelChristine Smallwood · 2021 · 1 honor
- 61The Lincoln Highway: A NovelAmor Towles · 2021 · 1 honor
- 62The Love Songs of W.E.B. Du BoisHonorée Fanonne Jeffers · 2021 · 1 honor
- 63The Love Songs of W.E.B. Du Bois: A NovelHonorée Fannone Jeffers · 2021 · 1 honor
- 64The Magician: A NovelColm Tóibín · 2021 · 1 honor
- 65The Paper Palace: A NovelMiranda Cowley Heller · 2021 · 1 honor
- 66The Personal Librarian: A NovelMarie Benedict and Victoria Christopher Murray · 2021 · 1 honor
- 67The Prophets: A NovelRobert Jones, Jr. · 2021 · 1 honor
- 68The Startup Wife: A NovelTahmima Anam · 2021 · 1 honor
- 69The Sweetness of Water: A NovelNathan Harris · 2021 · 1 honor
- 70The Twilight Zone: A NovelNona Fernández, translated by Natasha Wimmer · 2021 · 1 honor
- 71Trust: A NovelDomenico Starnone, translated by Jhumpa Lahiri · 2021 · 1 honor
- 72What Storm, What ThunderMyriam J.A. Chancy · 2021 · 1 honor
- 73What Strange Paradise: A NovelOmar El Akkad · 2021 · 1 honor
- 74When We Cease to Understand the WorldBenjamín Labatut · 2021 · 1 honor
- 75While We Were DatingJasmine Guillory · 2021 · 1 honor
- 76Wild Rain: Women Who DareBeverly Jenkins · 2021 · 1 honor
- 77Win Me Something: A NovelKyle Lucia Wu · 2021 · 1 honor
- 78Yellow Wife: A NovelSadeqa Johnson · 2021 · 1 honor
- 79Zorrie: A NovelLaird Hunt · 2021 · 1 honor